‘‘Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults. A Systematic Review and Meta-analysis’’
Is exercise capacity reduced more than 3 months after SARS-CoV-2 infection among those with long COVID-19 (LC) symptoms compared with recovered individuals without symptoms, and what patterns of limitations on cardiopulmonary exercise testing (CPET) are common?
In this systematic review and meta-analysis of 38 studies comprising 2160 participants, exercise capacity was reduced by 4.9 mL/kg/min among individuals with symptoms consistent with LC compared with individuals without symptoms more than 3 months after SARS-CoV-2 infection.
Findings among individuals with exertional intolerance suggest that deconditioning, dysfunctional breathing, chronotropic incompetence, and abnormal peripheral oxygen extraction and/or use may contribute to reduced exercise capacity.
These findings suggest that CPET may provide insight into the mechanisms for reduced exercise capacity among individuals with LC.
Article details:
- Title: ‘Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults. A Systematic Review and Meta-analysis’
- Authors: M.S. Durstenfeld, K. Sun, P. Tahir, M.J. Peluso, S.G. Deeks, M.A. Aras, D.J. Grandis, C.S. Long, A. Beatty, P.Y. Hsue,
- Published in: JAMA Netw Open. 2022;5(10):e2236057
- Link: https://doi.org/10.1001/jamanetworkopen.2022.36057
